ASSESSMENT OF MOLECULAR GENETIC RISK FACTORS FOR THE DEVELOPMENT OF CHOLELITHIASIS AND POSTOPERATIVE RECURRENCE IN OBESE PATIENTS
Keywords:
obesity, cholelithiasis, molecular genetics, gallstone recurrence, risk factors, polymorphism.Abstract
Cholelithiasis is one of the most common hepatobiliary diseases, particularly prevalent among obese patients. In recent years, increasing attention has been paid to molecular genetic factors that influence the development of gallstone disease and its recurrence after surgical treatment. This thesis aims to assess molecular genetic risk factors associated with the development of cholelithiasis in obese patients and the recurrence of the disease in the postoperative period. The analysis highlights the role of genetic polymorphisms involved in cholesterol metabolism, bile acid synthesis, inflammation, and insulin resistance. Understanding these factors may improve risk stratification, personalized treatment strategies, and long-term prevention of postoperative cholelithiasis recurrence.References
1.Portincasa P., et al. Gallstone disease: Symptoms and diagnosis. Lancet, 2018.
2.Stinton L.M., Shaffer E.A. Epidemiology of gallbladder disease. Gut and Liver, 2019.
3.Di Ciaula A., et al. Pathophysiology of gallstone recurrence. World Journal of Gastroenterology, 2020.
4.Buch S., et al. ABCG5/G8 polymorphisms and gallstone disease. Hepatology, 2017.
5.Wang D.Q., Carey M.C. Genetic factors in cholesterol gallstones. Journal of Lipid Research, 2018.
6.Grundy S.M. Obesity, insulin resistance, and gallstones. American Journal of Clinical Nutrition, 2019.
7.Chen C.H., et al. Cytokine gene polymorphisms and gallstone recurrence. BMC Gastroenterology, 2020.
8.Pollex R.L., Hegele R.A. Genetic determinants of lipid metabolism. Nature Reviews Endocrinology, 2018.
9.Lammert F., Sauerbruch T. Mechanisms of gallstone formation. Nature Reviews Gastroenterology, 2021.
10.Acalovschi M. Cholesterol gallstones: From genes to therapy. Journal of Gastrointestinal Surgery, 2019.
