LICHEN SCLEROSUS: CLINICAL, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS

Authors

  • Omasharifa binti Jamal Po Kursk State Medical University Candidate of Medical Sciences (PhD), Associate Professor Department of Obstetrics and Gynecology (Postgraduate Education) Author

Keywords:

lichen sclerosus, vulva, biopsy, histology, immunohistochemistry, p53, Ki-67, p16, CK17, malignant transformation.

Abstract

 Lichen sclerosus is a chronic inflammatory-atrophic dermatosis of the anogenital area characterized by itching, scarring, and risk of squamous cell carcinoma. The diagnosis is confirmed by biopsy: hyperkeratosis, epidermal atrophy, subepidermal cleft, collagen homogenization, and lichenoid infiltrate are typical features. The immunohistochemical profile with p53 positivity, low Ki-67, and negative p16/CK17 helps to verify lichen sclerosus and exclude neoplasia.

 

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Published

2025-12-19

Issue

Vol. 2 No. 2 (2025): Scottish International Conference on Multidisciplinary Research and Innovation – SICMRI 2025

Section

Articles