EARLY AND DIFFERENTIAL DIAGNOSIS OF THYROID NODULAR LESIONS IN WOMEN LIVING IN THE ARAL SEA REGION USING ULTRASOUND ELASTOGRAPHY AND THE TI-RADS SYSTEM
Keywords:
The aim of this study was to substantiate the clinical and diagnostic significance of combining conventional thyroid ultrasonography,Abstract
Thyroid nodular disease is one of the most common structural abnormalities of the thyroid gland and represents an important diagnostic problem in modern endocrinology and radiology. Although the majority of thyroid nodules are benign, a clinically significant proportion may be malignant. Therefore, the principal challenge is not merely to detect thyroid nodules but to distinguish lesions with a high probability of malignancy from those that can be safely monitored. This issue is of particular importance among women living in environmentally vulnerable areas of the Aral Sea region, where thyroid dysfunction and other environmental health problems have previously been documented.
References
1.Tessler F.N., Middleton W.D., Grant E.G., et al. ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee. Journal of the American College of Radiology. 2017;14(5):587–595.
2.Li W., Wang Y., Wen J., Zhang L., Sun Y. Diagnostic Performance of American College of Radiology TI-RADS: A Systematic Review and Meta-Analysis. American Journal of Roentgenology. 2021;216(1):38–47.
3.Haugen B.R., Alexander E.K., Bible K.C., et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1–133.
4.Russ G., Bonnema S.J., Erdogan M.F., Durante C., Ngu R., Leenhardt L. European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: EU-TIRADS. European Thyroid Journal. 2017;6:225–237.
5.Cantisani V., De Silvestri A., Scotti V., et al. US-Elastography With Different Techniques for Thyroid Nodule Characterization: Systematic Review and Meta-analysis. Frontiers in Oncology. 2022;12:845549.
6.Zhan J., Diao X.H., Jin J.M., et al. Real-time ultrasound elastography for differentiation of benign and malignant thyroid nodules: a meta-analysis. Ultrasound in Medicine & Biology. 2014.
7.Kubaev A.B., Kultanov B.Z., Tauesheva Z.B., et al. Evaluation of the functional state of the thyroid gland in women residing in the ecologically unfavorable Aral Sea region. Gigiena i Sanitariya. 2017;96(2):131–133.
8.Middleton W.D., Teefey S.A., Reading C.C., et al. Multiinstitutional comparison of the performance of ultrasound risk stratification systems for thyroid nodules. Radiology. 2017.
9.Angelopoulos N., Goulis D.G., Chrisogonidis I., et al. Elastography Enhances Diagnostic Accuracy of ACR TI-RADS in Thyroid Nodule Evaluation. Journal of Clinical Endocrinology & Metabolism. 2026;111(6):e1616–e1625.
